Harrison’s principle of internal medicine (17th Edition)

Name: Harrison’s principle of internal medicine

Edition: 17th

Author: Anthony S. Fauci; Eugene Braunwald; Dennis L. Kasper; Stephen L. Hauser; Dan L. Longo;J. Larry Jameson; Joseph Loscalzo

Subject: Internal Medicine

Language: English

Publisher: McGraw-Hill

Harrison's principle of internal medicine-17th Edition

Brief Introduction

This textbook has evolved simultaneously to keep step with these advances while at the same time maintaining an appreciation of the art of medicine and the principles underlying the optimal care of the patient. In shaping and revising this latest edition, the Editors have committed themselves to making the textbook an invaluable resource for students and practitioners coping with the demands of modern medicine.

The seventeenth edition of Harrison’s has a full-color format that draws from and extends the excellent appearance of the sixteenth edition to make the content more accessible and pleasant to read. The placement of color illustrations within the chapters rather than in the separate atlas was very favorably received by our sixteenth edition readers and has been continued in the current edition. Many changes to the design of this edition have been made in order to speed the reader’s navigation through the textual and visual materials. For example, tables have been shaded for ease of reading, citations in tables and illustrations are now more instantly notable and in color, and our Treatment sections in each chapter have been redesigned to allow even faster access. The new global icons call greater attention to key epidemiologic and clinical differences in the practice of medicine throughout the world.

Contents

PART 1
Introduction to Clinical Medicine

1 The Practice of Medicine
2 Global Issues in Medicine
3 Decision-Making in Clinical Medicine
4 Screening and Prevention of Disease
5 Principles of Clinical Pharmacology
6 Women’s Health
7 Medical Disorders during Pregnancy
8 Medical Evaluation of the Surgical Patient
9 Geriatric Medicine
10 Complementary and Alternative Medicine
11 Palliative and End-of-Life Care
e1 The Safety and Quality of Health Care
e2 Economic Considerations
e3 Racial and Ethnic Disparities in Health Care
e4 Ethical Issues in Clinical Medicine

PART 2
Cardinal Manifestations and Presentation of Diseases、

SECTION 1 PAIN
12 Pain: Pathophysiology and Management
13 Chest Discomfort
14 Abdominal Pain
15 Headache
16 Back and Neck Pain

SECTION 2 ALTERATIONS IN BODY TEMPERATURE
17 Fever and Hyperthermia
18 Fever and Rash
e5 Atlas of Rashes Associated with Fever
19 Fever of Unknown Origin
20 Hypothermia and Frostbite

SECTION 3 NERVOUS SYSTEM DYSFUNCTION
21 Syncope
22 Dizziness and Vertigo
23 Weakness and Paralysis
24 Gait and Balance Disorders
25 Numbness, Tingling, and Sensory Loss
26 Confusion and Delirium
e6 Memory Loss
27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders
28 Sleep Disorders

SECTION 4 DISORDERS OF EYES, EARS, NOSE, AND THROAT
29 Disorders of the Eye
30 Disorders of Smell, Taste, and Hearing
31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections
32 Oral Manifestations of Disease
e7 Atlas of Oral Manifestations of Disease

SECTION 5 ALTERATIONS IN CIRCULATORY AND RESPIRATORY FUNCTIONS
33 Dyspnea and Pulmonary Edema
34 Cough and Hemoptysis
35 Hypoxia and Cyanosis

……

……

PART 16
Neurologic Disorders

SECTION 1 DIAGNOSIS OF NEUROLOGIC DISORDERS
360 Mechanisms of Neurologic Diseases
361 Approach to the Patient with Neurologic Disease
362 Neuroimaging in Neurologic Disorders
e30 Atlas of Neuroimaging
e31 Electrodiagnostic Studies of Nervous System
e32 Technique of Lumbar Puncture

SECTION 2 DISEASES OF THE CENTRAL NERVOUS SYSTEM
363 Seizures and Epilepsy
364 Cerebrovascular Diseases
365 Dementia
366 Parkinson’s Disease and Other Extrapyramidal Movement Disorders
367 Hyperkinetic Movement Disorders
368 Ataxic Disorders
369 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
370 Disorders of the Autonomic Nervous System
371 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
372 Diseases of the Spinal Cord
373 Concussion and Other Head Injuries
374 Primary and Metastatic Tumors of the Nervous System
375 Multiple Sclerosis and Other Demyelinating Diseases
376 Meningitis, Encephalitis, Brain Abscess, and Empyema
377 Chronic and Recurrent Meningitis
378 Prion Diseases

SECTION 3 NERVE AND MUSCLE DISORDERS
379 Peripheral Neuropathy
380 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
381 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
382 Muscular Dystrophies and Other Muscle Diseases
383 Polymyositis, Dermatomyositis, and Inclusion Body Myositis
e33 Special Issues in Inpatient Neurologic Consultation
384 Chronic Fatigue Syndrome

SECTION 5 PSYCHIATRIC DISORDERS
385 Biology of Psychiatric Disorders
386 Mental Disorders

SECTION 6 ALCOHOLISM AND DRUG DEPENDENCY
387 Alcohol and Alcoholism
388 Opioid Drug Abuse and Dependence
389 Cocaine and Other Commonly Abused Drugs
390 Nicotine Addiction

PART 17
Poisoning, Drug Overdose, and Envenomation

e34 Heavy Metal Poisoning
e35 Poisoning and Drug Overdosage
391 Disorders Caused by Reptile Bites and Marine Animal Exposures
392 Ectoparasite Infestations and Arthropod Bites and Stings

PART 18
e-Chapters from International Advisory Editors

e36 Pulmonary Biomarkers in COPD
e37 Chagas’ Disease: Advances in Diagnosis and Management
e38 The Polypill
e39 Mitochondrial DNA and Heritable Traits and Diseases

APPENDIX
Laboratory Values of Clinical Importance

INDEX

Excerpts

Different types of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells for treatment of the brain), and somatic stem cells capable of generating cell types specific for the target rather than the donor organ (e.g., bone marrow mesenchymal stem cells for cardiac repair) (Chap. 66). ES cells self-renew endlessly so that a single cell line with carefully characterized traits can generate large numbers of cells that can be immunologically matched with potential transplant recipients. However, little is currently known about the mechanisms that govern differentiation of these cells or processes that limit their unbridled proliferation. Human ES cells are difficult to culture and grow slowly. ES cells tend to develop abnormal karyotypes and have the potential to form teratomas if they are not committed to the desired cell types before transplantation. The study of human ES cells has been controversial, and their use in clinical applications would be unacceptable to some patients and physicians despite their enormous potential. Somatic cell nuclear transfer (“therapeutic cloning”) represents an alternative method for creating ES cell lines that are genetically identical to the patient. It may also be possible to derive pluripotent stem cells from spermatogonia in the adult human testis, providing another strategy for obtaining genetically identical stem cells.

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